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Acidic Mammalian Chitinase and the Eye: Implications for Ocular Inflammatory Diseases

机译:酸性哺乳动物几丁质酶和眼睛:对眼炎性疾病的影响。

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摘要

Chitinases have an important role in the defense of organisms against chitin-containing parasites. An acidic mammalian chitinase (AMCase) has been detected in epithelial cells in lung tissue samples taken from patients with asthma as well as in conjunctival epithelium of patients with inflammatory ocular diseases. Particularly, elevated AMCase activity has been observed in ocular tissues of patients with vernal keratoconjunctivitis, seasonal allergic conjunctivitis, and in patients affected by dry eye syndrome. This enzyme is induced via a TH2-specific, IL-13-dependent pathway. AMCase may thus be a key mediator of IL-13-induced responses in TH2-driven inflammatory ocular diseases.
机译:几丁质酶在生物抵御含有几丁质的寄生虫方面具有重要作用。在取自哮喘患者的肺组织样品的上皮细胞以及炎性眼病患者的结膜上皮中已检测到酸性哺乳动物几丁质酶(AMCase)。尤其是,在患有春季角膜结膜炎,季节性变应性结膜炎的患者以及患有干眼症的患者的眼组织中,观察到AMCase活性升高。该酶是通过TH2特异性,IL-13依赖性途径诱导的。因此,AMCase可能是TH2驱动的炎症性眼病中IL-13诱导的反应的关键介体。

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